Rizvi F, Siddiqui R, DeFranco A, Xu H, Emelyanova L, Ross G, Shi Y, Holmuhamedov E, Tajik A, Jahangir A. Simvastatin prevents TFGB1 induced SMAD2/3 phosphorylation in human ventricular fibroblasts: involvement of protein phosphatase. Poster presented at: Aurora Scientific Day; May 25, 2016; Milwaukee, WI.
Poster presented at: Aurora Scientific Day; May 25, 2016; Milwaukee, WI.
Conclusions: Simvastatin prevents the pro-fibrotic cytokine, TGF-B1 induced differentiation of fibroblasts to myofibroblasts by SMAD2/3 dephosphorylation via phosphatases: PPM1A and PP2A.
The involvement of PPM1A and PP2A in the anti-fibrotic effect of simvastatin reveals novel signaling mediators that may be selectively targeted for prevention of myocardial injury-induced ventricular fibrosis and heart failure.