Title

Cushing syndrome: update on testing

Aurora Affiliations

Endocrine Research Laboratory, Aurora St. Luke's Medical Center, Aurora Research Institute

Abstract

Endogenous hypercortisolism (Cushing syndrome) is one of the most enigmatic diseases in clinical medicine. The diagnosis and differential diagnosis of Cushing syndrome depend on proper laboratory evaluation. In this review, an update is provided on selected critical issues in the diagnosis and differential diagnosis of Cushing syndrome: the use of late-night salivary cortisol in initial diagnosis and for postoperative surveillance, and the use of prolactin measurement to improve the performance of inferior petrosal sinus sampling to distinguish Cushing disease from ectopic adrenocorticotropic hormone (ACTH) syndrome during differential diagnosis of ACTH-dependent Cushing syndrome.

Document Type

Article

PubMed ID

25732641

DOI

10.1016/j.ecl.2014.10.005