Title

Harnessing the power of integrated mitochondrial biology and physiology: a special report on the NHLBI mitochondria in heart diseases initiative

Aurora Affiliations

Center for Integrative Research on Cardiovascular Aging, Cardiovascular Services and Department of Research

Abstract

Mitochondrial biology is the sum of diverse phenomena from molecular profiles to physiological functions. A mechanistic understanding of mitochondria in disease development, and hence the future prospect of clinical translations, relies on a systems-level integration of expertise from multiple fields of investigation. Upon the successful conclusion of a recent National Institutes of Health, National Heart, Lung, and Blood Institute initiative on integrative mitochondrial biology in cardiovascular diseases, we reflect on the accomplishments made possible by this unique interdisciplinary collaboration effort and exciting new fronts on the study of these remarkable organelles.

Document Type

Article

PubMed ID

26185209

DOI

10.1161/CIRCRESAHA.117.306693